The rule could be anything, as funny or as serious as you want. The universe will progress in a similar way that it has up until this point, unless your changed rule prevented it from doing so.

Some examples might be:

  • The invention of currency is not allowed.
  • Iron is slightly less stable.
  • The Ancient Greeks are able to cultivate Silphium, which does not go extinct now.
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    2 months ago

    After a little more thinking on this:

    Gender dysphoria? Nope! Shapeshifter. Furry? Nope Werebeing

    Basically, anything that is a deviation from bog standard human would have a magical reasoning behind it.