Yes, but Cain and/or Abel could have sex with Lilith and that offspring would not be the result of inbreeding.
Also, Eve could have sex with the offspring of Adam and Lilith and that would not be inbreeding.
After that everything else is unless there are more people.
And God got mad at Lilith for not being obedient and banished her so perhaps there were a series of Liliths. I think Eve was taken from the rib because that was supposed to make her less independently minded than creating her from the dust like Lilith.
The confusion comes from Genesis giving two creation accounts of a woman.
Genesis 1:27 So God created mankind in his own image,in the image of God he created them; male and female he created them.
then later…
Genesis 2:22 Then the LORD God made a woman from the rib he had taken out of the man, and he brought her to the man.
It appears that a man and a woman were created at the same time in Genesis 1:27, then later in Genesis 2:22 a woman was created from a rib
Lilith was made from the dust of the Earth like Adam. The story is that this is the reason why she was independent minded and as a result God made a new woman from the rib of man so that woman would be “from man” and more likely to be obedient to God and man. Not stating my opinion - that’s just what I read.